Watch Closely (one)mitotane decreases amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Mitotane is a solid inducer of cytochrome P-4503A4; observe when coadministered with CYP3A4 substrates for doable dosage changes.If this SPL is made up of inactivated NDCs mentioned by the FDA initiated comp